Enhancers and Transcriptional Regulation
نویسندگان
چکیده
منابع مشابه
Transcriptional Enhancers in the Regulation of T Cell Differentiation
The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are choreographed by the interplay between transcription factors and epigenetic regulators that act to restructure the genome, ultimately ensuring lineage-appropriate ...
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Regulatory DNAs serve as templates to bring weakly interacting transcription factors into close proximity so they can work synergistically to switch genes on and off in time and space. Most of these regulatory DNAs are enhancers that can work over long distances--a million base pairs or more in mammals--to control gene expression. Critical enhancers are sometimes even found within the introns o...
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Enhancers: Transcriptional enhancers are DNA sequences that control expression of nearby genes and direct tissue-specific, positive regulation of those genes (Karp, 2002; Griffiths, et al., 2002). The general mode of action of these sequences is that they associate with specific activator proteins (that are found in only certain tissues); this association of enhancer and activator facilitates t...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v128.22.sci-14.sci-14